The South Australian Museum is managed by a Board of eight men and women with a diverse range of business, arts, science and cultural expertise. They determine the strategic direction for the Museum, and are responsible for the obligations of the Museum as determined by the South Australian Museum Act 1976.

The day-to-day operations of the Museum are the responsibility of the Executive team. The Executive Team approve internal decisions relating to running the Museum and aid the Board in achieving the strategic objectives of the Museum.